Uncategorized 

Antimalarial Properties of Aqueous Crude Extracts of Gynostemma pentaphyllum and Moringa oleifera Leaves in Combination with Artesunate in Plasmodium berghei-Infected Mice

Authors: Voravuth Somsak, Preeyanuch Borkaew, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, and Butsarat Saiphet Source: Hindawi Publishing Corporation Journal of Tropical Medicine Volume 2016, Article ID 8031392, 6 pages Abstract: Due to the emergence and spread of malaria parasite with resistance to antimalarial drugs, discovery and development of new, safe, and affordable antimalarial are urgently needed. In this respect, medicinal plant extracts are targets to optimize antimalarial actions and restore efficacy of standard antimalarial drugs.The present study was aimed at determining the antimalarial activities of Gynostemma pentaphyllum and Moringa oleifera leaf extracts in…

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Cancer control Chemistry 

In Vitro Anticancer Activity of a Nonpolar Fraction from Gynostemma pentaphyllum (Thunb.) Makino

Authors: Yantao Li, Jiajun Huang, Wanjun Lin, Zhongwen Yuan, Senling Feng, Ying Xie, and WenzheMa Source: Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 6308649, 11 pages Abstract: Gynostemma pentaphyllum(Thunb.)Makino (GpM) has beenwidely used in traditional Chinesemedicine (TCM) for the treatment of various diseases including cancer. Most previous studies have focused primarily on polar fractions of GpM for anticancer activities. In this study, a nonpolar fraction EA1.3A from GpM showed potent growth inhibitory activities against four cancer cell lines with IC50 ranging from31.62 g/mL to 38.02 g/mL. Furthermore, EA1.3A…

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Diseases of organs 

The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.

Authors: Shuo-Chi Chou; Kwang-Wen Chen; Jaw-Shan Hwang; Wen-Tsoung Lu; Yin-Yi Chu; Jen-Der Lin; Hsiu-Jene Chang; Lai-Chu See Source: Alternative Therapies in Health & Medicine . May/Jun2006, Vol. 12 Issue 3, p34-39. 6p. Abstract: ContextOther than weight reduction by dieting or physical activity, there are no well-documented medical treatments for fatty liver disease. Objective • To evaluate the efficacy of the add-on Gynostemma pentaphyllum (GP) in research subjects with nonalcoholic fatty liver disease. Design . A randomized, single-blind, controlled clinical trial. Setting. Hospital-based clinic. Patients . Fifty-six research subjects who were diagnosed…

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Brain Health 

Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson’s Disease

Authors: Hyun Sook Choi, Mi Sook Park, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee and Myung Koo Lee Source: Molecules 2010, 15, 2814-2824; doi:10.3390/molecules15042814 Abstract: 6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side. Dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and norepinephrine levels were reduced to 19.1%, 52.3%, 47.1% and 67.4% in the striatum of 6-hydroxydopamine-lesioned rats compared to the control group, respectively. However, an oral administration of herbal ethanol extracts from Gynostemma…

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Blood Sugar Cholesterol Diabetes 

A Novel Insulin-releasing Substance, Phanoside, from the Plant Gynostemma pentaphyllum

Authors: Åke Norberg, Nguyen Khanh Hoa, Edvards Liepinsh, Dao Van Phan, Nguyen Duy Thuan, Hans Jörnvall, Rannar Sillard and Claes-Göran Östenson Source: THE JOURNAL OF BIOLOGICAL CHEMISTRY  Vol. 279, No. 40, Issue of October 1, pp. 41361–41367, 2004 Abstract: Extracts from Gynostemma pentaphyllum Makino (Cucurbitaceae), a Southeast Asian herb, has been reported to affect numerous activities resulting in antitumor, cholesterol-lowering, immunopotentiating, antioxidant, and hypoglycemic effects. We have isolated one active compound by ethanol extraction, distribution in n-butyl alcohol/water, solid phase extraction/separation, and several rounds of reverse phase high pressure liquid chromatography. We…

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Cholesterol 

Phytopreventative Anti-Hyperlipidemic Effects Of Gynostemma Pentaphyllum In Rats

Authors: Samer Megallia , Fugen Aktanb , Neal M. Daviesc, Basil D. Roufogalisa Source: J Pharm Pharmaceut Sci (www.cspsCanada.org) 8(3):507-515, 2005 Abstract: Gynostemma pentaphyllum is widely used in traditional Chinese medicine. Preliminary studies indicate Gynostemma isolated triterpine glycosides lower cholesterol. Our studies examine anti-hyperlipidemic effects of gypenosides. Ful text: gynostemma

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Inflammation 

Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway

Authors: Tom Hsun-Wei Huang, Yuhao Li, Valentina Razmovski-Naumovski, Van Hoan Tran, George Qian Li, Colin C. Duke & Basil D. Roufogalis* Source: Journal of Biomedical Science (2006) 13:535–548 Abstract: Nuclear factor (NF)-j B is important in the generation of inflammation. Besides regulating lipid metabolism, peroxisome proliferator-activated receptor (PPAR)-a activators also reduce NF-j B activation to terminate activation of inflammatory pathways. Gynostemma pentaphyllum  (GP) has been used to treat various inflammatory diseases and hyperlipidemia. Here, we demonstrate that GP extract and one of its main components, Gypenoside XLIX (Gyp-XLIX) inhibited LPS-induced NF-j B activation…

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Chemistry 

Novel Dammarane-Type Glycosides from Gynostemma pentaphyllum

Authors: Feng YIN, Lihong HU,* and Ruixiang PAN Source: Chem. Pharm. Bull. 52(12) 1440—1444 (2004) Vol. 52, No. 12 Abstract: Three new dammarane glycosides (1—3), together with five known compounds, gypenoside LXIX (4), gylongiposide I (5), gypenoside XLVIII (6), allantion (7) and vitexin (8) were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum. Compounds 5, 7, and 8 were isolated from this plant for the first time. Their structures were elucidated by 1D and 2D NMR spectra interpretation as well as by chemical degradation. Ful text: 52_1440

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Chemistry 

Chemistry and pharmacology of Gynostemma pentaphyllum

Authors: Valentina Razmovski-Naumovski , Tom Hsun-Wei Huang , Van Hoan Tran, George Qian Li, Colin C. Duke & Basil D. Roufogalis* Source:  Phytochemistry Reviews (2005) 4: 197–219 Abstract: In traditional Chinese medicine, Gynostemma pentaphyllum (Thunb.) Makino is a herbal drug of extreme versatility and has been extensively researched in China. The dammarane saponins isolated from Gynostemma pentaphyllum, namely gypenosides or gynosaponins, are believed to be the active components responsible for its various biological activities and reported clinical effects. This review attempts to encompass the available literature on Gynostemma pentaphyllum, from…

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Blood Sugar Diabetes 

Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients

Authors: V. T. T. Huyen,1,2,3 D. V. Phan,2 P. Thang,3 N. K. Hoa,4 and C. G. Östenson1 Source: Journal of Nutrition and Metabolism Volume 2013, Article ID 765383, 7 pages Abstract:  To evaluate the efect of the traditional Vietnamese herb Gynostemma pentaphyllum tea on insulin sensitivity in drug-naıve type 2 diabetic patients. Methods. Patients received GP or placebo tea 6 g daily for four weeks and vice versa with a 2-week wash- out period. At the end of each period, a somatostatin-insulin-glucose infusion test (SIGIT) was performed to evaluate the…

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