Authors: V. T. T. Huyen,1,2,3 D. V. Phan,2 P. Thang,3 N. K. Hoa,4 and C. G. Östenson1
Source: Journal of Nutrition and Metabolism Volume 2013, Article ID 765383, 7 pages
Abstract: To evaluate the efect of the traditional Vietnamese herb Gynostemma pentaphyllum tea on insulin sensitivity in drug-naıve type 2 diabetic patients. Methods. Patients received GP or placebo tea 6 g daily for four weeks and vice versa with a 2-week wash- out period. At the end of each period, a somatostatin-insulin-glucose infusion test (SIGIT) was performed to evaluate the insulin sensitivity. Fasting plasma glucose (FPG), HbA1C , and oral glucose tolerance tests and insulin levels were measured before, during, and a er the treatment. Results. FPG and steady-state plasma glucose (SIGIT mean) were lower a er GP treatment compared to placebo treatment ( < 0.001). e levels of FPG in the control group were slightly reduced to 0.2 ± 1.5 versus 1.9 ± 1.0 mmol/L in GP group ( < 0.001), and the effect on FPG was reversed a er exchanging treatments. The glycometabolic improvements were achieved without any major change of circulating insulin levels. ere were no changes in lipids, body measurements, blood pressure, and no reported hypoglycemias or acute adverse effects regarding kidney and liver parameters. Conclusion. e results of this study suggested that the GP tea exerted antidiabetic effect by improving insulin sensitivity.
Full Text: 765383