Authors José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesinos
Affiliation Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain
Parkinsonʼs disease is a progressive neurodege- nerative dysfunction characterized by the loss of pigmented dopaminergic neurons of the nigros- triatal system with a consequent dopamine de- crease. The reduction of dopamine levels pro- duces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. Treatments for Parkinsonʼs disease aim for improving these motor symptoms by increasing the dopaminergic signal in the striatum with levodopa in combina- tion with enzyme inhibitors or anticholinergic drugs. Nevertheless, natural products can act as neuroprotective agents by reducing the progres- sion of the disease and the inflammatory process. In the present review, we have compiled data on the principal medicinal plants and natural products as potential antiparkinsonian agents. They act by different mechanisms, such as the inhibi- tion of α-synuclein condensation, reduction of ox- idative stress and neuro-inflammation, increase of dopaminergic neurons survival, or the block- ade of the A2 A receptor.
Full Text: s-0042-107081