The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.

Authors: Shuo-Chi Chou; Kwang-Wen Chen; Jaw-Shan Hwang; Wen-Tsoung Lu; Yin-Yi Chu; Jen-Der Lin; Hsiu-Jene Chang; Lai-Chu See

Source: Alternative Therapies in Health & Medicine . May/Jun2006, Vol. 12 Issue 3, p34-39. 6p.

Abstract: ContextOther than weight reduction by dieting or physical activity, there are no well-documented medical treatments for fatty liver disease. Objective • To evaluate the efficacy of the add-on Gynostemma pentaphyllum (GP) in research subjects with nonalcoholic fatty liver disease. Design . A randomized, single-blind, controlled clinical trial. Setting. Hospital-based clinic. Patients . Fifty-six research subjects who were diagnosed with nonalcoholic fatty liver by abdominal ultrasound scanning. Interventions • The treatment group and the control group followed a controlled diet for 2 months. After 2 months, the treatment group continued to diet and received 80 mL GP extraction for 4 months; the control group continued to diet and received a placebo capsule for 4 months. Main Outcome Measures• Body mass index (BMI), biochemistry data, and fatty liver score were measured at baseline, at 2 months, and at 6 months. Results • After 2 months of dieting, BMI and most biochemistry data decreased in both study groups. There were no significant differences in BMI or biochemistry data at month 2 between the 2 study groups. At month 6, BMI, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase, alkaline phosphatase, insulin (ALP), insulin resistance index (HOMA-TR), and fatty liver score were reduced in both groups. The treatment group saw significant reductions in BMI, AST, ALP, insulin, and HOMA-IR, however. Changes in uric acid levels in the 2 groups from month 2 to month 6 were statistically significant (P = .028) Conclusion • GP is an effective adjunct treatment to diet therapy for patients with nonalcoholic fatty liver disease.

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