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Antimalarial Properties of Aqueous Crude Extracts of Gynostemma pentaphyllum and Moringa oleifera Leaves in Combination with Artesunate in Plasmodium berghei-Infected Mice

Authors: Voravuth Somsak, Preeyanuch Borkaew, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, and Butsarat Saiphet Source: Hindawi Publishing Corporation Journal of Tropical Medicine Volume 2016, Article ID 8031392, 6 pages Abstract: Due to the emergence and spread of malaria parasite with resistance to antimalarial drugs, discovery and development of new, safe, and affordable antimalarial are urgently needed. In this respect, medicinal plant extracts are targets to optimize antimalarial actions and restore efficacy of standard antimalarial drugs.The present study was aimed at determining the antimalarial activities of Gynostemma pentaphyllum and Moringa oleifera leaf extracts in…

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Cancer control Chemistry 

In Vitro Anticancer Activity of a Nonpolar Fraction from Gynostemma pentaphyllum (Thunb.) Makino

Authors: Yantao Li, Jiajun Huang, Wanjun Lin, Zhongwen Yuan, Senling Feng, Ying Xie, and WenzheMa Source: Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 6308649, 11 pages Abstract: Gynostemma pentaphyllum(Thunb.)Makino (GpM) has beenwidely used in traditional Chinesemedicine (TCM) for the treatment of various diseases including cancer. Most previous studies have focused primarily on polar fractions of GpM for anticancer activities. In this study, a nonpolar fraction EA1.3A from GpM showed potent growth inhibitory activities against four cancer cell lines with IC50 ranging from31.62 g/mL to 38.02 g/mL. Furthermore, EA1.3A…

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