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Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release

Authors: Chenghui Liao, Kai Zheng, Yan Li, Hong Xu, Qiangrong Kang, Long Fan, Xiaopeng Hu, Zhe Jin, Yong Zeng, Xiaoli Kong, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Yifei Wang, Zhendan He Source: Oncotarget, Vol. 7, No. 30 Abstract: Esophageal cancer is one of the leading cause of cancer mortality in the world. Due to the increased drug and radiation tolerance, it is urgent to develop novel anticancer agent that triggers nonapoptotic cell death to compensate for apoptosis resistance. In this study, we show that treatment with gypenoside L (Gyp-L), a…

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Saponins from Chinese Medicines as Anticancer Agents

Authors: Xiao-Huang Xu, Ting Li, Chi Man Vivienne Fong, Xiuping Chen, Xiao-Jia Chen, Yi-Tao Wang, Ming-Qing Huang,  and Jin-Jian Lu Source: Molecules 2016, 21, 1326; doi:10.3390/molecules21101326 Abstract: Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo…

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Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

Authors: Xiaoya Shang , Yu Chao, Yuan Zhang , Chengyuan Lu , Chunlan Xu and Weining Niu Source: Molecules 2016, 21, 1085; doi:10.3390/molecules21081085 Abstract: The immunomodulatory and antioxidant activities of crude polysaccharides extracted from Gynostemma pentaphyllum  Makino (GPMPP) were investigated. GPMPP was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in the molar ratio of 1.39:3.76:1.00:1.64:4.98:5.88. In vivo studies showed GPMPP significantly increased the spleen and thymus indices, activated the macrophage phagocytosis and NK cells, and exhibited activity on none or Con A/LPS-stimulated splenocytes in a dose-dependent manner in C57BL/6 mice. Moreover, GPMPP…

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Chemical constituents from a Gynostemma laxum and their antioxidant and neuroprotective activities

Authors: Ji Yeon Seo, Sang Kyum Kim, Phi Hung Nguyen, Ju Yong Lee, Pham Ha Thanh Tung, Sang Hyun Sung and Won Keun Oh Source: Seo et al. Chin Med (2017) 12:15 DOI 10.1186/s13020-017-0136-y Abstract: Background: A few bioactivities of constituents from Gynostemma laxum, which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents from G. laxum although the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether…

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Anti‑cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)

Authors: Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie and Wenzhe Ma Source: Li et al. Chin Med (2016) 11:43 DOI 10.1186/s13020-016-0114-9 Abstract: Gynostemma pentaphyllum (Thunb.) Makino (GpM) ( Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by…

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The healing power of flavonoids

Authors: REBECCA JACOBS Source: THE HEALING POWER OF FLAVONOIDS October, 2014 Abstract: Ever wonder where blueberries, plums, beets, and all of those wonderful deep blue and purple fruits and veggies get their vibrant colors from? Flavonoids! Flavonoids are fantastic for our health, and balance. They act as antioxidants in the body which help to ward off free radicals which in turn helps to prevent oxidative damage to cells. Flavonoids are so powerful, powerful enough that they can actually participate in metabolism, help with the use of calcium in our bodies, and help with inflammation. Flavonoids also help with a whole handful of other…

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Antimalarial Properties of Aqueous Crude Extracts of Gynostemma pentaphyllum and Moringa oleifera Leaves in Combination with Artesunate in Plasmodium berghei-Infected Mice

Authors: Voravuth Somsak, Preeyanuch Borkaew, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, and Butsarat Saiphet Source: Hindawi Publishing Corporation Journal of Tropical Medicine Volume 2016, Article ID 8031392, 6 pages Abstract: Due to the emergence and spread of malaria parasite with resistance to antimalarial drugs, discovery and development of new, safe, and affordable antimalarial are urgently needed. In this respect, medicinal plant extracts are targets to optimize antimalarial actions and restore efficacy of standard antimalarial drugs.The present study was aimed at determining the antimalarial activities of Gynostemma pentaphyllum and Moringa oleifera leaf extracts in…

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Cancer control Chemistry 

In Vitro Anticancer Activity of a Nonpolar Fraction from Gynostemma pentaphyllum (Thunb.) Makino

Authors: Yantao Li, Jiajun Huang, Wanjun Lin, Zhongwen Yuan, Senling Feng, Ying Xie, and WenzheMa Source: Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 6308649, 11 pages Abstract: Gynostemma pentaphyllum(Thunb.)Makino (GpM) has beenwidely used in traditional Chinesemedicine (TCM) for the treatment of various diseases including cancer. Most previous studies have focused primarily on polar fractions of GpM for anticancer activities. In this study, a nonpolar fraction EA1.3A from GpM showed potent growth inhibitory activities against four cancer cell lines with IC50 ranging from31.62 g/mL to 38.02 g/mL. Furthermore, EA1.3A…

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Diseases of organs 

The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.

Authors: Shuo-Chi Chou; Kwang-Wen Chen; Jaw-Shan Hwang; Wen-Tsoung Lu; Yin-Yi Chu; Jen-Der Lin; Hsiu-Jene Chang; Lai-Chu See Source: Alternative Therapies in Health & Medicine . May/Jun2006, Vol. 12 Issue 3, p34-39. 6p. Abstract: ContextOther than weight reduction by dieting or physical activity, there are no well-documented medical treatments for fatty liver disease. Objective • To evaluate the efficacy of the add-on Gynostemma pentaphyllum (GP) in research subjects with nonalcoholic fatty liver disease. Design . A randomized, single-blind, controlled clinical trial. Setting. Hospital-based clinic. Patients . Fifty-six research subjects who were diagnosed…

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Brain Health 

Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson’s Disease

Authors: Hyun Sook Choi, Mi Sook Park, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee and Myung Koo Lee Source: Molecules 2010, 15, 2814-2824; doi:10.3390/molecules15042814 Abstract: 6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side. Dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and norepinephrine levels were reduced to 19.1%, 52.3%, 47.1% and 67.4% in the striatum of 6-hydroxydopamine-lesioned rats compared to the control group, respectively. However, an oral administration of herbal ethanol extracts from Gynostemma…

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