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Blood Sugar Cholesterol Diabetes 

A Novel Insulin-releasing Substance, Phanoside, from the Plant Gynostemma pentaphyllum

Authors: Åke Norberg, Nguyen Khanh Hoa, Edvards Liepinsh, Dao Van Phan, Nguyen Duy Thuan, Hans Jörnvall, Rannar Sillard and Claes-Göran Östenson Source: THE JOURNAL OF BIOLOGICAL CHEMISTRY  Vol. 279, No. 40, Issue of October 1, pp. 41361–41367, 2004 Abstract: Extracts from Gynostemma pentaphyllum Makino (Cucurbitaceae), a Southeast Asian herb, has been reported to affect numerous activities resulting in antitumor, cholesterol-lowering, immunopotentiating, antioxidant, and hypoglycemic effects. We have isolated one active compound by ethanol extraction, distribution in n-butyl alcohol/water, solid phase extraction/separation, and several rounds of reverse phase high pressure liquid chromatography. We…

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Cholesterol 

Phytopreventative Anti-Hyperlipidemic Effects Of Gynostemma Pentaphyllum In Rats

Authors: Samer Megallia , Fugen Aktanb , Neal M. Daviesc, Basil D. Roufogalisa Source: J Pharm Pharmaceut Sci (www.cspsCanada.org) 8(3):507-515, 2005 Abstract: Gynostemma pentaphyllum is widely used in traditional Chinese medicine. Preliminary studies indicate Gynostemma isolated triterpine glycosides lower cholesterol. Our studies examine anti-hyperlipidemic effects of gypenosides. Ful text: gynostemma

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Inflammation 

Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway

Authors: Tom Hsun-Wei Huang, Yuhao Li, Valentina Razmovski-Naumovski, Van Hoan Tran, George Qian Li, Colin C. Duke & Basil D. Roufogalis* Source: Journal of Biomedical Science (2006) 13:535–548 Abstract: Nuclear factor (NF)-j B is important in the generation of inflammation. Besides regulating lipid metabolism, peroxisome proliferator-activated receptor (PPAR)-a activators also reduce NF-j B activation to terminate activation of inflammatory pathways. Gynostemma pentaphyllum  (GP) has been used to treat various inflammatory diseases and hyperlipidemia. Here, we demonstrate that GP extract and one of its main components, Gypenoside XLIX (Gyp-XLIX) inhibited LPS-induced NF-j B activation…

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Chemistry 

Novel Dammarane-Type Glycosides from Gynostemma pentaphyllum

Authors: Feng YIN, Lihong HU,* and Ruixiang PAN Source: Chem. Pharm. Bull. 52(12) 1440—1444 (2004) Vol. 52, No. 12 Abstract: Three new dammarane glycosides (1—3), together with five known compounds, gypenoside LXIX (4), gylongiposide I (5), gypenoside XLVIII (6), allantion (7) and vitexin (8) were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum. Compounds 5, 7, and 8 were isolated from this plant for the first time. Their structures were elucidated by 1D and 2D NMR spectra interpretation as well as by chemical degradation. Ful text: 52_1440

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Chemistry 

Chemistry and pharmacology of Gynostemma pentaphyllum

Authors: Valentina Razmovski-Naumovski , Tom Hsun-Wei Huang , Van Hoan Tran, George Qian Li, Colin C. Duke & Basil D. Roufogalis* Source:  Phytochemistry Reviews (2005) 4: 197–219 Abstract: In traditional Chinese medicine, Gynostemma pentaphyllum (Thunb.) Makino is a herbal drug of extreme versatility and has been extensively researched in China. The dammarane saponins isolated from Gynostemma pentaphyllum, namely gypenosides or gynosaponins, are believed to be the active components responsible for its various biological activities and reported clinical effects. This review attempts to encompass the available literature on Gynostemma pentaphyllum, from…

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Blood Sugar Diabetes 

Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients

Authors: V. T. T. Huyen,1,2,3 D. V. Phan,2 P. Thang,3 N. K. Hoa,4 and C. G. Östenson1 Source: Journal of Nutrition and Metabolism Volume 2013, Article ID 765383, 7 pages Abstract:  To evaluate the efect of the traditional Vietnamese herb Gynostemma pentaphyllum tea on insulin sensitivity in drug-naıve type 2 diabetic patients. Methods. Patients received GP or placebo tea 6 g daily for four weeks and vice versa with a 2-week wash- out period. At the end of each period, a somatostatin-insulin-glucose infusion test (SIGIT) was performed to evaluate the…

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Brain Health 

Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs*

Authors José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesinos Affiliation Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain   Abstract Parkinsonʼs disease is a progressive neurodege- nerative dysfunction characterized by the loss of pigmented dopaminergic neurons of the nigros- triatal system with a consequent dopamine de- crease. The reduction of dopamine levels pro- duces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. Treatments for Parkinsonʼs disease aim for improving these motor symptoms by increasing the dopaminergic signal in…

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Blood Sugar Cardiovascular Health Cholesterol Diabetes 

Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Fatty Rat

Authors: Samer Megalli, Neal M. Davies, and Basil D. Roufogalis Faculty of Pharmacy and Herbal Medicines Research and Education Centre University of Sydney, Building Al5, Sydney NSW 2006. ABSTRACT – Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including elevated cholesterol. We have examined the pharma-cological anti-hyperlipidemic and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250 mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density lipoprotein cholesterol levels (33%). These effects…

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