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Brain Health 

Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson’s Disease

Authors: Hyun Sook Choi, Mi Sook Park, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee and Myung Koo Lee Source: Molecules 2010, 15, 2814-2824; doi:10.3390/molecules15042814 Abstract: 6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side. Dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and norepinephrine levels were reduced to 19.1%, 52.3%, 47.1% and 67.4% in the striatum of 6-hydroxydopamine-lesioned rats compared to the control group, respectively. However, an oral administration of herbal ethanol extracts from Gynostemma…

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Brain Health 

Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs*

Authors José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesinos Affiliation Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain   Abstract Parkinsonʼs disease is a progressive neurodege- nerative dysfunction characterized by the loss of pigmented dopaminergic neurons of the nigros- triatal system with a consequent dopamine de- crease. The reduction of dopamine levels pro- duces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. Treatments for Parkinsonʼs disease aim for improving these motor symptoms by increasing the dopaminergic signal in…

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