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Anti‑cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)

Authors: Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie and Wenzhe Ma Source: Li et al. Chin Med (2016) 11:43 DOI 10.1186/s13020-016-0114-9 Abstract: Gynostemma pentaphyllum (Thunb.) Makino (GpM) ( Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by…

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Blood Sugar Cardiovascular Health Cholesterol Diabetes 

Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Fatty Rat

Authors: Samer Megalli, Neal M. Davies, and Basil D. Roufogalis Faculty of Pharmacy and Herbal Medicines Research and Education Centre University of Sydney, Building Al5, Sydney NSW 2006. ABSTRACT – Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including elevated cholesterol. We have examined the pharma-cological anti-hyperlipidemic and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250 mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density lipoprotein cholesterol levels (33%). These effects…

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