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Anti‑cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)

Authors: Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie and Wenzhe Ma Source: Li et al. Chin Med (2016) 11:43 DOI 10.1186/s13020-016-0114-9 Abstract: Gynostemma pentaphyllum (Thunb.) Makino (GpM) ( Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by…

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Blood Sugar Cholesterol Diabetes 

A Novel Insulin-releasing Substance, Phanoside, from the Plant Gynostemma pentaphyllum

Authors: Åke Norberg, Nguyen Khanh Hoa, Edvards Liepinsh, Dao Van Phan, Nguyen Duy Thuan, Hans Jörnvall, Rannar Sillard and Claes-Göran Östenson Source: THE JOURNAL OF BIOLOGICAL CHEMISTRY  Vol. 279, No. 40, Issue of October 1, pp. 41361–41367, 2004 Abstract: Extracts from Gynostemma pentaphyllum Makino (Cucurbitaceae), a Southeast Asian herb, has been reported to affect numerous activities resulting in antitumor, cholesterol-lowering, immunopotentiating, antioxidant, and hypoglycemic effects. We have isolated one active compound by ethanol extraction, distribution in n-butyl alcohol/water, solid phase extraction/separation, and several rounds of reverse phase high pressure liquid chromatography. We…

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Blood Sugar Diabetes 

Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients

Authors: V. T. T. Huyen,1,2,3 D. V. Phan,2 P. Thang,3 N. K. Hoa,4 and C. G. Östenson1 Source: Journal of Nutrition and Metabolism Volume 2013, Article ID 765383, 7 pages Abstract:  To evaluate the efect of the traditional Vietnamese herb Gynostemma pentaphyllum tea on insulin sensitivity in drug-naıve type 2 diabetic patients. Methods. Patients received GP or placebo tea 6 g daily for four weeks and vice versa with a 2-week wash- out period. At the end of each period, a somatostatin-insulin-glucose infusion test (SIGIT) was performed to evaluate the…

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Blood Sugar Cardiovascular Health Cholesterol Diabetes 

Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Fatty Rat

Authors: Samer Megalli, Neal M. Davies, and Basil D. Roufogalis Faculty of Pharmacy and Herbal Medicines Research and Education Centre University of Sydney, Building Al5, Sydney NSW 2006. ABSTRACT – Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including elevated cholesterol. We have examined the pharma-cological anti-hyperlipidemic and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250 mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density lipoprotein cholesterol levels (33%). These effects…

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