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Gynostemma pentaphyllum (GP) and Superoxide Dismutase (SOD)

Authors: Chi and colleagues Source: Abstract: In a study published in 2012, Chi and colleagues tried to investigate the effects of polysaccharide from Gynostemma pentaphyllum on antioxidant activity in skeletal muscle of mice exercised to exhaustion. Researchers used a forced swim test of mice and determined the levels of glucose, glutathione peroxidase, superoxide dismutase and other markers. They found increased antioxidant enzyme activities due to the increased levels of SOD. (10) Another animal study examined the protective effects of gypenosides from…

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The healing power of flavonoids

Authors: REBECCA JACOBS Source: THE HEALING POWER OF FLAVONOIDS October, 2014 Abstract: Ever wonder where blueberries, plums, beets, and all of those wonderful deep blue and purple fruits and veggies get their vibrant colors from? Flavonoids! Flavonoids are fantastic for our health, and balance. They act as antioxidants in the body which help to ward off free radicals which in turn helps to prevent oxidative damage to cells. Flavonoids are so powerful, powerful enough that they can actually participate in metabolism, help with the use of calcium in our bodies, and help with inflammation. Flavonoids also help with a whole handful of other…

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Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway

Authors: Tom Hsun-Wei Huang, Yuhao Li, Valentina Razmovski-Naumovski, Van Hoan Tran, George Qian Li, Colin C. Duke & Basil D. Roufogalis* Source: Journal of Biomedical Science (2006) 13:535–548 Abstract: Nuclear factor (NF)-j B is important in the generation of inflammation. Besides regulating lipid metabolism, peroxisome proliferator-activated receptor (PPAR)-a activators also reduce NF-j B activation to terminate activation of inflammatory pathways. Gynostemma pentaphyllum  (GP) has been used to treat various inflammatory diseases and hyperlipidemia. Here, we demonstrate that GP extract and one of its main components, Gypenoside XLIX (Gyp-XLIX) inhibited LPS-induced NF-j B activation…

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