Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway

Authors: Tom Hsun-Wei Huang, Yuhao Li, Valentina Razmovski-Naumovski, Van Hoan Tran, George Qian Li, Colin C. Duke & Basil D. Roufogalis* Source: Journal of Biomedical Science (2006) 13:535–548 Abstract: Nuclear factor (NF)-j B is important in the generation of inflammation. Besides regulating lipid metabolism, peroxisome proliferator-activated receptor (PPAR)-a activators also reduce NF-j B activation to terminate activation of inflammatory pathways. Gynostemma pentaphyllum  (GP) has been used to treat various inflammatory diseases and hyperlipidemia. Here, we demonstrate that GP extract and one of its main components, Gypenoside XLIX (Gyp-XLIX) inhibited LPS-induced NF-j B activation…

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