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Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

Authors: Xiaoya Shang , Yu Chao, Yuan Zhang , Chengyuan Lu , Chunlan Xu and Weining Niu Source: Molecules 2016, 21, 1085; doi:10.3390/molecules21081085 Abstract: The immunomodulatory and antioxidant activities of crude polysaccharides extracted from Gynostemma pentaphyllum  Makino (GPMPP) were investigated. GPMPP was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in the molar ratio of 1.39:3.76:1.00:1.64:4.98:5.88. In vivo studies showed GPMPP significantly increased the spleen and thymus indices, activated the macrophage phagocytosis and NK cells, and exhibited activity on none or Con A/LPS-stimulated splenocytes in a dose-dependent manner in C57BL/6 mice. Moreover, GPMPP…

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Chemical constituents from a Gynostemma laxum and their antioxidant and neuroprotective activities

Authors: Ji Yeon Seo, Sang Kyum Kim, Phi Hung Nguyen, Ju Yong Lee, Pham Ha Thanh Tung, Sang Hyun Sung and Won Keun Oh Source: Seo et al. Chin Med (2017) 12:15 DOI 10.1186/s13020-017-0136-y Abstract: Background: A few bioactivities of constituents from Gynostemma laxum, which has been collected in Vietnam, have been reported until now. There is no report about the effects of constituents from G. laxum although the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase-1 (HO-1) antioxidant defense system is involved in neuroprotection in the brain. Therefore, we investigated whether…

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