Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

Authors: Xiaoya Shang , Yu Chao, Yuan Zhang , Chengyuan Lu , Chunlan Xu and Weining Niu Source: Molecules 2016, 21, 1085; doi:10.3390/molecules21081085 Abstract: The immunomodulatory and antioxidant activities of crude polysaccharides extracted from Gynostemma pentaphyllum  Makino (GPMPP) were investigated. GPMPP was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in the molar ratio of 1.39:3.76:1.00:1.64:4.98:5.88. In vivo studies showed GPMPP significantly increased the spleen and thymus indices, activated the macrophage phagocytosis and NK cells, and exhibited activity on none or Con A/LPS-stimulated splenocytes in a dose-dependent manner in C57BL/6 mice. Moreover, GPMPP…

Read More