Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs*

Authors José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesinos Affiliation Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain   Abstract Parkinsonʼs disease is a progressive neurodege- nerative dysfunction characterized by the loss of pigmented dopaminergic neurons of the nigros- triatal system with a consequent dopamine de- crease. The reduction of dopamine levels pro- duces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. Treatments for Parkinsonʼs disease aim for improving these motor symptoms by increasing the dopaminergic signal in…

Read More