Authors: Chi and colleagues
Abstract: In a study published in 2012, Chi and colleagues tried to investigate the effects of polysaccharide from Gynostemma pentaphyllum on antioxidant activity in skeletal muscle of mice exercised to exhaustion. Researchers used a forced swim test of mice and determined the levels of glucose, glutathione peroxidase, superoxide dismutase and other markers. They found increased antioxidant enzyme activities due to the increased levels of SOD. (10)
Another animal study examined the protective effects of gypenosides from Gynostemma pentaphyllum on fatty liver disease. The results have shown improvement in hepatic activity markers including lower levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity. On the other hand, there was an increase in high density lipoprotein cholesterol (HDL-C or good cholesterol) and superoxide dismutase activity. These results confirm the potential of gypenosides to prevent liver fatty degeneration in fatty liver disease through modulating lipid metabolism, ameliorating liver dysfunction and reducing oxidative stress.