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Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release

Authors: Chenghui Liao, Kai Zheng, Yan Li, Hong Xu, Qiangrong Kang, Long Fan, Xiaopeng Hu, Zhe Jin, Yong Zeng, Xiaoli Kong, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Yifei Wang, Zhendan He Source: Oncotarget, Vol. 7, No. 30 Abstract: Esophageal cancer is one of the leading cause of cancer mortality in the world. Due to the increased drug and radiation tolerance, it is urgent to develop novel anticancer agent that triggers nonapoptotic cell death to compensate for apoptosis resistance. In this study, we show that treatment with gypenoside L (Gyp-L), a…

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Saponins from Chinese Medicines as Anticancer Agents

Authors: Xiao-Huang Xu, Ting Li, Chi Man Vivienne Fong, Xiuping Chen, Xiao-Jia Chen, Yi-Tao Wang, Ming-Qing Huang,  and Jin-Jian Lu Source: Molecules 2016, 21, 1326; doi:10.3390/molecules21101326 Abstract: Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo…

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Anti‑cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)

Authors: Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie and Wenzhe Ma Source: Li et al. Chin Med (2016) 11:43 DOI 10.1186/s13020-016-0114-9 Abstract: Gynostemma pentaphyllum (Thunb.) Makino (GpM) ( Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by…

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The healing power of flavonoids

Authors: REBECCA JACOBS Source: THE HEALING POWER OF FLAVONOIDS October, 2014 Abstract: Ever wonder where blueberries, plums, beets, and all of those wonderful deep blue and purple fruits and veggies get their vibrant colors from? Flavonoids! Flavonoids are fantastic for our health, and balance. They act as antioxidants in the body which help to ward off free radicals which in turn helps to prevent oxidative damage to cells. Flavonoids are so powerful, powerful enough that they can actually participate in metabolism, help with the use of calcium in our bodies, and help with inflammation. Flavonoids also help with a whole handful of other…

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Cancer control Chemistry 

In Vitro Anticancer Activity of a Nonpolar Fraction from Gynostemma pentaphyllum (Thunb.) Makino

Authors: Yantao Li, Jiajun Huang, Wanjun Lin, Zhongwen Yuan, Senling Feng, Ying Xie, and WenzheMa Source: Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 6308649, 11 pages Abstract: Gynostemma pentaphyllum(Thunb.)Makino (GpM) has beenwidely used in traditional Chinesemedicine (TCM) for the treatment of various diseases including cancer. Most previous studies have focused primarily on polar fractions of GpM for anticancer activities. In this study, a nonpolar fraction EA1.3A from GpM showed potent growth inhibitory activities against four cancer cell lines with IC50 ranging from31.62 g/mL to 38.02 g/mL. Furthermore, EA1.3A…

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