You are here

Gynostemma pentaphyllum (GP) and Superoxide Dismutase (SOD)

Authors: Chi and colleagues Source: Abstract: In a study published in 2012, Chi and colleagues tried to investigate the effects of polysaccharide from Gynostemma pentaphyllum on antioxidant activity in skeletal muscle of mice exercised to exhaustion. Researchers used a forced swim test of mice and determined the levels of glucose, glutathione peroxidase, superoxide dismutase and other markers. They found increased antioxidant enzyme activities due to the increased levels of SOD. (10) Another animal study examined the protective effects of gypenosides from…

Read More
Cholesterol Uncategorized 

Profiling analysis of amino acids from hyperlipidaemic rats treated with Gynostemma pentaphyllum and atorvastatin

Authors: Yinan Wang, Min Zhao, Miao Wang & Chunjie Zhao Source: Pharmaceutical Biology, 54:10, 2254-2263, DOI: 10.3109/13880209.2016.1152278 Abstract:  Context Gynostemma pentaphyllum (Thunb.) Makino has been used in traditional medicine for the treatment of hyperlipidaemic with a long history. Objective: The objective of this study was to evaluate the influence of Gynostemma pentaphyllum (GP) and atorvastatin on amino acids from the plasma and liver tissue of hyperlipidaemic rats. Materials and methods The rats were fed a high-fat diet continuously for 11 weeks for the construction of hyperlipidaemic model. The hyperlipidaemic rats were treated…

Read More

Anti‑cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)

Authors: Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie and Wenzhe Ma Source: Li et al. Chin Med (2016) 11:43 DOI 10.1186/s13020-016-0114-9 Abstract: Gynostemma pentaphyllum (Thunb.) Makino (GpM) ( Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by…

Read More

Antimalarial Properties of Aqueous Crude Extracts of Gynostemma pentaphyllum and Moringa oleifera Leaves in Combination with Artesunate in Plasmodium berghei-Infected Mice

Authors: Voravuth Somsak, Preeyanuch Borkaew, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, and Butsarat Saiphet Source: Hindawi Publishing Corporation Journal of Tropical Medicine Volume 2016, Article ID 8031392, 6 pages Abstract: Due to the emergence and spread of malaria parasite with resistance to antimalarial drugs, discovery and development of new, safe, and affordable antimalarial are urgently needed. In this respect, medicinal plant extracts are targets to optimize antimalarial actions and restore efficacy of standard antimalarial drugs.The present study was aimed at determining the antimalarial activities of Gynostemma pentaphyllum and Moringa oleifera leaf extracts in…

Read More
Cancer control Chemistry 

In Vitro Anticancer Activity of a Nonpolar Fraction from Gynostemma pentaphyllum (Thunb.) Makino

Authors: Yantao Li, Jiajun Huang, Wanjun Lin, Zhongwen Yuan, Senling Feng, Ying Xie, and WenzheMa Source: Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 6308649, 11 pages Abstract: Gynostemma pentaphyllum(Thunb.)Makino (GpM) has beenwidely used in traditional Chinesemedicine (TCM) for the treatment of various diseases including cancer. Most previous studies have focused primarily on polar fractions of GpM for anticancer activities. In this study, a nonpolar fraction EA1.3A from GpM showed potent growth inhibitory activities against four cancer cell lines with IC50 ranging from31.62 g/mL to 38.02 g/mL. Furthermore, EA1.3A…

Read More
Diseases of organs 

The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.

Authors: Shuo-Chi Chou; Kwang-Wen Chen; Jaw-Shan Hwang; Wen-Tsoung Lu; Yin-Yi Chu; Jen-Der Lin; Hsiu-Jene Chang; Lai-Chu See Source: Alternative Therapies in Health & Medicine . May/Jun2006, Vol. 12 Issue 3, p34-39. 6p. Abstract: ContextOther than weight reduction by dieting or physical activity, there are no well-documented medical treatments for fatty liver disease. Objective • To evaluate the efficacy of the add-on Gynostemma pentaphyllum (GP) in research subjects with nonalcoholic fatty liver disease. Design . A randomized, single-blind, controlled clinical trial. Setting. Hospital-based clinic. Patients . Fifty-six research subjects who were diagnosed…

Read More
Brain Health 

Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson’s Disease

Authors: Hyun Sook Choi, Mi Sook Park, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee and Myung Koo Lee Source: Molecules 2010, 15, 2814-2824; doi:10.3390/molecules15042814 Abstract: 6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side. Dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and norepinephrine levels were reduced to 19.1%, 52.3%, 47.1% and 67.4% in the striatum of 6-hydroxydopamine-lesioned rats compared to the control group, respectively. However, an oral administration of herbal ethanol extracts from Gynostemma…

Read More
Blood Sugar Cholesterol Diabetes 

A Novel Insulin-releasing Substance, Phanoside, from the Plant Gynostemma pentaphyllum

Authors: Åke Norberg, Nguyen Khanh Hoa, Edvards Liepinsh, Dao Van Phan, Nguyen Duy Thuan, Hans Jörnvall, Rannar Sillard and Claes-Göran Östenson Source: THE JOURNAL OF BIOLOGICAL CHEMISTRY  Vol. 279, No. 40, Issue of October 1, pp. 41361–41367, 2004 Abstract: Extracts from Gynostemma pentaphyllum Makino (Cucurbitaceae), a Southeast Asian herb, has been reported to affect numerous activities resulting in antitumor, cholesterol-lowering, immunopotentiating, antioxidant, and hypoglycemic effects. We have isolated one active compound by ethanol extraction, distribution in n-butyl alcohol/water, solid phase extraction/separation, and several rounds of reverse phase high pressure liquid chromatography. We…

Read More

Phytopreventative Anti-Hyperlipidemic Effects Of Gynostemma Pentaphyllum In Rats

Authors: Samer Megallia , Fugen Aktanb , Neal M. Daviesc, Basil D. Roufogalisa Source: J Pharm Pharmaceut Sci ( 8(3):507-515, 2005 Abstract: Gynostemma pentaphyllum is widely used in traditional Chinese medicine. Preliminary studies indicate Gynostemma isolated triterpine glycosides lower cholesterol. Our studies examine anti-hyperlipidemic effects of gypenosides. Ful text: gynostemma

Read More

Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway

Authors: Tom Hsun-Wei Huang, Yuhao Li, Valentina Razmovski-Naumovski, Van Hoan Tran, George Qian Li, Colin C. Duke & Basil D. Roufogalis* Source: Journal of Biomedical Science (2006) 13:535–548 Abstract: Nuclear factor (NF)-j B is important in the generation of inflammation. Besides regulating lipid metabolism, peroxisome proliferator-activated receptor (PPAR)-a activators also reduce NF-j B activation to terminate activation of inflammatory pathways. Gynostemma pentaphyllum  (GP) has been used to treat various inflammatory diseases and hyperlipidemia. Here, we demonstrate that GP extract and one of its main components, Gypenoside XLIX (Gyp-XLIX) inhibited LPS-induced NF-j B activation…

Read More